May 21, 2013


CLINICAL CARDIOLOGY CONCEPTS
for the dog and cat

Michael R. O'Grady, DVM, MSc, Diplomate ACVIM (Cardiology)
M. Lynne O'Sullivan, DVM, DVSc, Diplomate ACVIM (Cardiology)

 
  Heartworm Therapy
Adulticides    
Ivermectin   Dog 6 ug/kg (PO) monthly for 2 years,
(not for Collies less than 4.5 kg)  
To reduce worm burdens  
Cat 24 ug/kg (PO) monthly for 2 years  
Melarsomine   Dog 2.5 mg/kg IM q 24 hr minimal for 2 days, +/- repeat in 4 months   Hepatotoxic, nephrotoxic.
Treatment of last resort for cats in stable condition.  
Cat probably lethal in cats  
Thiacetarsamide   Dog 2.2 mg/kg BID (IV) for 4 treatments   Hepatotoxic, nephrotoxic, phlebitis  
Cat 2.2 mg/kg BID (IV) for 4 treatments  
Microfilaricides    
Ivermectin   Dog 6 ug/kg (PO),
(not for Collies less than 4.5 kg)  
Shock-like reaction, lethargy, anorexia, vomiting  
Cat unknown  
Levamisole   Dog 11 mg/kg (PO) for 7 to 12 days   Vomiting, CNS signs, peripheral neuropathy  
Cat undetermined, usually not required  
Milbemycin   Dog 0.5 mg/kg (PO) once monthly   None, possible shock-like reaction if dog is microfilaremic  
Cat 2 mg/kg (PO) once monthly  
Moxidectin   Dog 2.2 mg/kg topically once monthly   None, possible shock-like reaction if dog is microfilaremic  
Cat 0.9 mg/kg topically once monthly  
Selamectin   Dog 6 mg/kg topically once monthly   None even if animal is microfilaremic  
Cat 6 mg/kg topically once monthly  
Preventives    
Diethylcarbamazine   Dog 5.5 - 6.5 mg/kg SID(PO)   Shock-like if dog is microfilaremic  
Cat not required  
Ivermectin   Dog 6 ug/kg (PO) once monthly (not for Collies less than 4.5 kg)   None, possible shock-like reaction if dog is microfilaremic  
Cat not required  
Milbemycin   Dog 0.5 mg/kg (PO) once monthly   None, possible shock-like reaction if dog is microfilaremic  
Cat 2 mg/kg (PO) once monthly  
Moxidectin   Dog 2.2 mg/kg topically once monthly   None, possible shock-like reaction if dog is microfilaremic  
Cat 0.9 mg/kg topically once monthly  
Selamectin   Dog 6 mg/kg topically once monthly   None even if animal is microfilaremic  
Cat 6 mg/kg topically once monthly